WNT3 and Hypertension: Therefore, we propose that by releasing miR-637-mediated inhibition of both WNT3 and CAMK2N2 expression, LOC646616 upregulation in hypertension promotes WNT/β-catenin pathway activation both directly, through enhanced WNT3 expression, and indirectly, by preventing CAMKII-mediated inhibition (Figure 8).