The morphometric variables that differed significantly between epithelioid and sarcomatoid MM by univariate analysis (nuclear grade, tumor cellularity, p53 protein, PMS2 mismatch repair protein, hyaluronic acid, elastic fibers, total collagen, Col I, Col V, and CD8+ T lymphocytes) were grouped by hierarchical cluster analyses independent of clinicopathological variables; two clusters of patients with 67 subjects in cluster 1 (CL I) and 15 in cluster 2 (CL II) were identified (Figure 5A,B; Table 3). This evidence concerns the gene TP53 and neoplasm.