Across limbic (III-IV and I-IV) and neocortical (V-VI) ROIs, tau positivity was seen in Aβ-positive cases and in 2 carriers of an MAPT R406W mutation associated with the formation of AD-like PHFs.44 In general, [18F]RO948 did not bind significantly in the included non-AD disorders. The gene discussed is MAPT; the disease is Alzheimer disease.