However, both the CCR2/CCL2 axis and neutrophils are reported to be ‘pro-tumor’ (Coffelt et al., 2016; Qian et al., 2011) and therefore systemic treatment targeting neutrophils or the CCR2/CCL2 axis in humans may be particularly beneficial in that they decrease tumor size and abrogate CNS dysfunction. Here, CCR2 is linked to neoplasm.