A series of studies utilizing a mouse model of inflammatory liver disease showed that ‘sickness behaviors’ could be attenuated if myeloid cell recruitment to the brain was abrogated via any one of several different interventions, including: 1) administration of a P-selectin inhibitor (Kerfoot et al., 2006), 2) deleting Ccr2 (D'Mello et al., 2009), and 3) inhibiting microglia activation with minocycline (D'Mello et al., 2013). This evidence concerns the gene CCR2 and liver disorder.