To determine whether the decreased muscle mass loss in CCR2KO mice was due to decreased muscle proteolysis, we assessed levels of transcripts key for muscle proteolysis in the gastrocnemius, including Fbxo32 (Mafbx), Trim63 (Murf1), and Foxo1, which we previously showed are induced by CNS inflammation (Braun et al., 2011). The gene discussed is FOXO1; the disease is inflammatory response.