It is possible that the differences we observed in gastrocnemius catabolism between WT and CCR2KO tumor animals were due to differences in food intake, but the fact that we observed a significant decrease in induction of the catabolic genes Mafbx, Murf1, and Foxo1 in CCR2KO tumor animals, which are not induced by decreased food intake/starvation (Braun et al., 2011), makes this unlikely. The gene discussed is FOXO1; the disease is neoplasm.