All these findings combined, strongly suggest, quite strikingly, that Ena/VASP proteins execute conserved and prominent, positive regulatory functions in adhesive, 2D cell migration, in a fashion irrespective of cell type (melanoma cells and fibroblast alike) and thus type of mesenchymal migration and/or signaling condition, as induced by extracellular matrices (laminin versus fibronectin). This evidence concerns the gene ENAH and melanoma.