The Mannava's laboratory found that knocking out the c‐Myc gene in human melanoma cell lines could reduce the expression of several rate‐limiting enzymes during nucleotide synthesis, such as thymidylate synthase, HX nucleotide dehydrogenase 2 (IMPDH2) and PRPS2 resulting in a decrease in intracellular nucleotide levels and cell proliferation.17 The gene discussed is PRPS2; the disease is melanoma.