As a result, we found that up-regulated MASPIN nucleus and cytoplasm expression was associated with poor OS in NSCLC (HR = 1.43, 95% CI = 1.01–2.04, P<0.05) without obvious heterogeneity (I2 = 33.00%, Ph<0.05, Figure 2A). The gene discussed is SERPINB5; the disease is non-small cell lung carcinoma.