In order to uncover the effect of MASPIN cytoplasm localization on OS, we conducted a subgroup analysis, and the results showed that MASPIN overexpression was associated with poor OS in NSCLC (HR = 1.45, 95% CI = 1.01–2.07, P<0.05, Figure 2B) and LUAD (HR = 1.44, 95% CI = 0.33–6.26, P=0.626, Figure 2C). The gene discussed is SERPINB5; the disease is non-small cell lung carcinoma.