Next, OS was analyzed in NSCLC, LUAD, and LUSC related to SERPINB5 mRNA expression, and we found that NSCLC and LUAD patients with high expression of SERPINB5 mRNA had poorer prognosis (HR = 1.69, 95% CI = 1.47–1.95, P<0.001; HR = 1.88, 95% CI = 1.49–2.38, P<0.001; respectively, Figure 7A,B), and there was no statistically difference in LUSC patients (HR = 0.79, 95% CI = 0.61–1.03, P=0.081, Figure 7C). The gene discussed is SERPINB5; the disease is non-small cell lung carcinoma.