One study has uncovered that knockdown of TUG1 via shRNA can inhibit the formation of renal cell carcinoma in vivo and in vitro through the miR-299-3p/VEGF axis [18], and one other study by Yang et al. [19] has revealed that lncRNA TUG1 participates in pulmonary vascular remodeling of hypoxic pulmonary hypertension mice through miR-374c-mediated Foxc1. This evidence concerns the gene FOXC1 and hereditary clear cell renal cell carcinoma.