TGFB1 and neoplasm: Mathematical modeling experiments demonstrate that concentration gradients of EMT inducing signals (such as TGF-β) from the tumor-stroma boundary can generate distinct spatial patterning within tumors where complete EMT cells cluster toward the invasive edge and hybrid E/M cells are generated closer to the interior of the tumor where the concentrations of these signaling molecules are lower (Bocci et al., 2019).