AKT1 and breast cancer: A distinct attempt to target AKT activity was made by Chen and colleagues, who recently discovered that a natural methoxylated analog of resveratrol, 3,5,4′-trimethoxystilbene (MR-3), can block EMT and the invasion of breast cancer cells via restoring GSK3β activity and inhibiting the phosphorylation of AKT (Tsai et al., 2013).