LOXL2 and neoplasm: In addition to regulating EMT-associated transcription factors, LOXL2 additionally regulates the recruitment of bone marrow progenitor cells (c-kit+/Sca-1+) to the lungs and enhances premetastatic niche formation, demonstrating multiple, simultaneous means by which tumor cells may enhance their metastatic potential (Canesin et al., 2015).