A distinct attempt to target AKT activity was made by Chen and colleagues, who recently discovered that a natural methoxylated analog of resveratrol, 3,5,4′-trimethoxystilbene (MR-3), can block EMT and the invasion of breast cancer cells via restoring GSK3β activity and inhibiting the phosphorylation of AKT (Tsai et al., 2013). This evidence concerns the gene GSK3B and breast cancer.