Tumor cell expression of lysyl oxidase-like 2 (LOXL2) has been shown to regulate the EMT transcription factor Snail1 and can additionally interact with the bHLH transcription factor E47 to downregulate E-cadherin and induce EMT (Canesin et al., 2015; Salvador et al., 2017). This evidence concerns the gene CDH1 and neoplasm.