A recent study evaluated plasma concentrations of collagen type III alpha 1 chain (COL3A1, also called PIIINP), cartilage oligomeric matrix protein (COMP), and colony-stimulating factor 2 antibodies (anti-CSF2 antibodies) at baseline in pediatric CD patients and followed up the patients for 36 months. The gene discussed is COL3A1; the disease is Cowden disease.