Andrographis paniculata, a medicinal herb cross the BBB, has been demonstrated that inhibits U87 as well as U251 GBM cell proliferation through inducing cell cycle arrest by reduced Cdk1 and Cdc25C expression and also displayed inhibition of PI3K/Akt/mTOR signaling pathway (Li et al., 2012). This evidence concerns the gene AKT1 and glioblastoma.