Several autophagy-related genes (Beclin-1, Agt4, and Atg5) are upregulated, and the silencing of these genes negatively affects cell survival; as a result, the extent of autophagy in chronic myeloid leukemia (CML) appears to be related to the status of CSCs in the tumor (Rothe et al., 2014; Karvela et al., 2016). Here, ATG5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.