NSAID treatment increases LC3-II levels and decreases p62 levels, with a simultaneous decrease in the levels of numerous stemness-related markers, including Oct4, CD44, c-Myc, and mutant p53 in CD44highK562 cells, indicating that NSAIDs promote autophagy in CML cells (Moon et al., 2019). Here, SQSTM1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.