STAT3 and diffuse large B-cell lymphoma: Moreover, in ABC-DLBCL, NF-κB enhances the secretion of interleukin (IL)-6 and/or IL-10, leading to the activation of JAK/STAT3 signaling, further enhancing NF-κB activity and its target gene expression (Lam et al., 2008a; Zegeye et al., 2018).