SETDB1 levels are greatly increased in numerous cancers, including lung cancer (Lafuente-Sanchis et al., 2016; Chen B. et al., 2018), and is an important epigenetic regulator involved in control of histone methylation in tumorigenesis, dysregulation of histone methylation, and aberrant miRNA profiling, contributing to tumorigenesis and progression (Chen Y. et al., 2018; Michalak et al., 2019). The gene discussed is SETDB1; the disease is lung cancer.