For example, down-regulation of miR-145-5p can be attributed to methylation of the miR-145 promoter in brain metastasis of lung cancer (Donzelli et al., 2015), while Wang et al. found that H3K27me3 can bind to the miR-145 core promoter region to co-regulate LASP1 expression in colorectal cancer cells (Wang et al., 2016). The gene discussed is LASP1; the disease is lung cancer.