SOD1 and non-small cell lung carcinoma: To further verify the impact of SOD1 levels on prognosis in patients with NSCLC, we used the GEPIA analysis tool (Tang et al., 2017) to evaluate the expression levels of SOD1 and NSCLC survival progression in large database, and we found that SOD1 expression was significantly negatively correlated with OS in patients with ADC (P = 0.014, Figure 2D-a), but positively correlated with SOD1 expression the OS in SCC patients (P = 0.032, Figure 2D-b).