Hence, to account for this, we designed a novel hybrid, multi-compartmental multicellular model consisting of (i) an external/outer collagen-coated cuboid compartment for growth of the stromal cells, i.e., stellate and endothelial cells, and (ii) an internal/inner FN-coated cylindrical compartment for growth of the pancreatic cancer cells (Figure 1). Here, FN1 is linked to pancreatic neoplasm.