Concerning this, as Penniger JM and colleagues declared in the last days, the availability of recombinant ACE2 (rhACE2; APN01, GSK2586881), its safety profile, and the anti-inflammatory effects (mainly linked to its ability to reduce IL-6 plasma levels) will be the impetus to rapidly launch a pilot trial of rhACE2 as a hopeful treatment option for patients with severe COVID-19 (clinical trials.gov#NCT04287686). This evidence concerns the gene ACE2 and COVID-19.