HSD3B1 and hypospadias: SNPs in the hydroxysteroid (17-beta) dehydrogenase 3 (HSD17B3), hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1 (HSD3B1), and stAR-related lipid transfer domain containing 3 (STARD3) genes were associated to an increased hypospadias risk for moderate and severe hypospadias but not for mild hypospadias (11).