We treated SW480 and SW620 cells with lovastatin (5 and 30 μM, respectively) for 48 h, but also included the CRC cell line HCT15 (5 μM), which has been reported to endogenously express elevated ABCB1 levels and thus shows increased multi-drug resistance, but also expresses considerable amounts of MACC1 (21, 25, 26). Here, MACC1 is linked to colorectal carcinoma.