In vitro studies conducted on epithelial cancer cells have shown that when cancer cell lines of different origin are incubated with either supernatants derived from a mixed lymphocyte population, or a mix of inflammatory cytokines (TGF-β, IFN-γ, TNF-α) they undergo through a series of changes typical of the EMT, namely remarkable enhancement of snail1 and snail2 genes transcription and down-regulation of E-cadherin expression, accompanied by an up-regulation of Vimentin. This evidence concerns the gene TGFB1 and cancer.