In this case, tmTNFα expressed in breast cancer cells, transmit outside-to-inside signals in the cells promoting activation of NF-κB through the p42/p44 MAPK signaling pathway to promote glutathione S-transferase- π (GST-π) expression, an enzyme that reduces intracellular doxorubicin levels. This evidence concerns the gene NFKB1 and breast carcinoma.