In a study of men with persistently elevated prostate PSA levels but negative digital rectal examination and negative biopsy, Ga68 PSMA-PET guided biopsy was found to be useful in identifying clinically significant primary prostate cancer (Gleason ≥ 7), with 100% overall sensitivity, and 76–88% specificity (36). The gene discussed is FOLH1; the disease is Familial prostate cancer.