Prostate-specific biopsy was not recommended in five Caucasian men with ICC-PSA-negative CTC, instead non-prostate specific follow-up tests detected kidney cancer in one patient, and B-cell lymphoma in another, while no other tumors were detected in 3/6 men with ICC-PSA-negative CTC (Table 2, group ED3). The gene discussed is KLK3; the disease is kidney cancer.