In this study we analyzed a series of 26 GIST negative for KIT/PDGFRA/BRAF/NRAS/KRAS mutations and with intact SDH complex, analyzed in two different Diagnostic Centers (local and referral), identifying three NF1-mutated samples, in agreement with a previous study showing a relevant frequency of NF1 mutations in quadruple-negative GIST cases (11). The gene discussed is SDHB; the disease is gastrointestinal stromal tumor.