While CD8+ T-cells were clearly present in the vicinity of KS tumor tissue in excess of the numbers in normal skin, it is possible that recruited CD8+ T-cells undergo inhibition from exposure to the cytokines produced by the tumor cells like IL-10 and TGF-β, that may impede access to the tumor parenchyma [17, 38]. This evidence concerns the gene CD8A and Kaposi's sarcoma.