Furthermore, TBX2 acts as a neuroblastoma core regulatory circuitry component that promotes MYCN/FOXM1-mediated reactivation of DREAM targets (Decaesteker et al., 2018), while CLOCK genes are closely associated with cancer development, particularly in endocrine tissues (Angelousi et al., 2019). This evidence concerns the gene KCNIP3 and neuroblastoma.