The role of transcription factors in OM pathology became apparent through the studies of mutant mice lacking Eya4, Evi1, Tgif, Ets1, and Fli1 genes (Hardisty-Hughes et al., 2006; Parkinson et al., 2006; Depreux et al., 2008; Tateossian et al., 2013; Carpinelli et al., 2015). Here, TGIF1 is linked to ocular melanoma.