In a lung cancer model, CAR T-cell-targeting tissue factor (TF), found to be overexpressed in squamous cell carcinoma and adenocarcinoma of nonsmall cell lung cancer as well as melanoma, suppressed the cancer in the xenograft and prevented the metastasis of TF-expressing tumor cells without associated toxicity (Zhang Q. et al., 2017). The gene discussed is TF; the disease is squamous cell carcinoma.