These molecules enable the tumor to downregulate NK-cell-activating receptors including NKp30, NKp44, or NKG2D, as well as tumor necrosis factor-related apoptosis-inducing ligand (Baginska et al., 2013; Vitale et al., 2014; Zenarruzabeitia et al., 2017; Park A. et al., 2018; Nayyar et al., 2019; Konjevic et al., 2019). This evidence concerns the gene NCR2 and neoplasm.