Moreover, CSC uses ALDH to survive chemotherapy by blocking signal transducer and activator of transcription 3 (STAT3)–nuclear factor kappa B (NF-κB) signaling, a pathway that can diminish the accumulation of ALDH1A1 and sensitize tumor cells to chemotherapy (Canino et al., 2015; Zhao, 2016). This evidence concerns the gene STAT3 and neoplasm.