Supernatants obtained from split anergy NK cells were reported to mediate CSC differentiation mainly via IFN-γ and TNF-α, which in turn were documented to reduce the degree of tumor growth and induce tumor cell resistance to NK cell killing (Tseng et al., 2014, 2015a,b; Bui et al., 2015; Kaur K. et al., 2018). The gene discussed is IFNG; the disease is neoplasm.