High expression of EpCAM has been reported to play a key role in breast, head and neck squamous cell carcinoma, and colon cancers progression, as reported with CD133 and CD90; EpCAM is crucial for CSC proliferation, differentiation, and renewal (Visvader and Lindeman, 2008; van der Gun et al., 2010). Here, EPCAM is linked to head and neck squamous cell carcinoma.