Tumor-associated cells residing at the tumor site, including immature dendritic cells (DCs), Tregs, tumor-associated macrophages, and myeloid-derived suppressor cells, produce various molecules such as TGF-β, IL-4, IL-10, prostaglandin E2, and idoleamine 2,3-dioxygenase (Stojanovic et al., 2013; Konjevic et al., 2019). This evidence concerns the gene IL4 and neoplasm.