CHEK1 and non-small cell lung carcinoma: However, Yu et al. (2012) demonstrated in mice that miR-195 regulates the response of NSCLC cells to microtubule-targeting agents (MTAs) by targeting CHEK1. The overexpression of CHEK1 contributes to the development of resistance to MTAs, while the knockout of CHEK1 contributes to the enhancement of MTAs and inhibition of the growth of NSCLC cells.