The three genes (YTHDC2, YTHDF2, and METTL3) incorporated in the prognosis risk model were upregulated in the LC patients in both LIRI-JP and LIHC datasets, which are similar to those of previous studies (Yuan et al., 2014; Chen et al., 2018). The gene discussed is METTL3; the disease is laryngotracheoesophageal cleft.