Some studies focused on the DNA damage repair-related genes, such as XRCC1 (Tiseo et al., 2013), ERCC1 (Ren et al., 2012), TP53, PARP1 (Shiraishi et al., 2010), and XPD (Santarpia et al., 2017) in NSCLC, etc. Our group has found that rs12334811, rs11615, and rs2299939 in DNA repair pathway genes might regulate the expression and affect the DNA damage repair and thereby impact the efficacy of radio-chemotherapy and the survival time of NSCLC (Wang et al., 2016). The gene discussed is ERCC1; the disease is non-small cell lung carcinoma.