Zhuo et al. (2016) have observed that polymorphism re619586A >G in lncRNA MALAT1 contributes to PAH susceptibility in Chinese people. Zhang et al. (2016) have identified that lncRNA BCYRN1 promotes the proliferation and migration of rat airway smooth muscle cells in asthma via elevating the expression of TRPC1. All of these findings indicate that lncRNAs also play critical roles in the regulation of PAH, but evidence in this area is still rarely reported. Here, TRPC1 is linked to pulmonary arterial hypertension.