NLRP3 and Alzheimer disease: Intracerebral injection of fibrillar Aβ-containing brain homogenates enhances tau phosphorylation and aggregation in Tau22 mice, which is blocked by NLRP3 or ASC deficiency (150), suggesting that Aβ-induced NLRP3 inflammasome activation exacerbates tau pathology in AD and its animal models.