IL2 and neoplasm: During this period, lymphodepleting regimen eradicates homeostatic cytokine sinks, such as IL-7, IL-2, and IL-15, eliminates unwanted immunosuppressive cells, such as regulatory T cells and myeloid-derived suppressor cells and downregulates indoleamine 2,3-dioxygenase (IDO) in tumor cells (67, 69).