CD8A and neoplasm: By conducting single cell transcriptomic analysis and chromatin accessibility, these researchers found that transcription factors NR4A1, NR4A2, and NR4A3 are overexpressed and play pivotal roles in driving CD8+ T cell exhaustion in both murine CAR-modified T cells and endogenous lymphocytes as well as their human counterparts which were chronically exposed to tumor or viral infection (80).