APCs express at least three immunoreceptors that belong to the calcium-dependent (C-type) lectin family: DC-specific intercellular adhesion molecule 3 grabbing non integrin (DC-SIGN, CD209), DEC-205 (CD205), and Langerin (CD207), which can be utilized by pathogens to initiate infection (20, 38–40). Here, LY75 is linked to infection.