As shown in Figure 7, the ratio of CD103+CD8+T cells to CD8+ T cells from neoplasm-superficial samples (59.64 ± 6.02%) was obviously more than that from EBUS-TBNA samples (21.24 ± 5.68%, P < 0.01), peripheral blood (5.83 ± 0.95%, P < 0.01), and malignant pleural effusion (1.50 ± 0.45%, P < 0.01), which indicated more CD8+ T cells differentiated into CD103+CD8+ T cells in peripheral tumor microenvironment and less within the center of tumor. Here, CD8A is linked to neoplasm.