pDCs were shown to promote MM progression by secreting factors that enhance MM cell growth (i.e., IL-6), MM chemotaxis (i.e., CXCL-12), and BM angiogenesis (i.e., VEGF), and induce local immunosuppression (i.e., IL-10) (90, 97, 108). This evidence concerns the gene CXCL12 and Miyoshi myopathy.