And MC4R rs12970134 and PROX1 rs340841 were significantly associated with the increased risk of GDM in the three models (dominant model: adjusted OR = 1.22, 95%CI = 1.01–1.47, P = 0.040 for rs12970134; adjusted OR =1.33, 95%CI = 1.09–1.63, P = 0.005 for rs340841; recessive model: adjusted OR = 1.91, 95%CI = 1.23–2.95, P = 0.003 for rs12970134; adjusted OR =1.28, 95%CI = 1.03–1.59, P = 0.028 for rs340841; additive model: adjusted OR =1.25, 95%CI = 1.07–1.46, P = 0.006 for rs12970134; adjusted OR =1.22, 95%CI = 1.07–1.39, P = 0.002 for rs340841). This evidence concerns the gene MC4R and gestational diabetes.