Results: We observed that FTO rs1121980 and KCNQ1 rs163182 conferred a decreased GDM risk in the dominant and additive model [additive model: OR (95% CI) = 0.79 (0.67–0.94), P = 0.007 for rs1121980; OR(95%CI) = 0.84 (0.73–0.96), P = 0.009 for rs163182], whereas MC4R rs12970134 and PROX1 rs340841 conferred an increased GDM risk in the dominant, recessive, and additive model [additive model: OR(95%CI) = 1.25 (1.07–1.46), P = 0.006 for rs12970134; OR(95%CI) = 1.22 (1.07–1.39), P = 0.002 for rs340841). Here, MC4R is linked to gestational diabetes.