Accordingly, ZNF577 methylation levels in the leukocytes from women with breast cancer were higher in patients with obesity than in patients with normal-weight (p = 0.002; Figure 2A), and in postmenopausal than in premenopausal women (p = 0.022; Figure 2B). Here, ZNF577 is linked to obesity due to melanocortin 4 receptor deficiency.