A more recent study on peripheral blood mononuclear cells (PBMCs) of children with obesity and normal weight peers found that polyphenol cherry extracts have a beneficial effect on in vitro osteoclastogenesis determining a dose-dependent reduction of the expression of osteoclast genes, such as calcitonin receptor, cathepsin K and RANK. The gene discussed is TNFRSF11A; the disease is obesity due to melanocortin 4 receptor deficiency.