Evidence from the literature on severe sepsis (22–30), acute respiratory distress syndrome (ARDS) (31–35), and trauma (14, 36) provides strong support that the degree of NF-κB-driven elevation in inflammatory biomarkers at ICU entry and during ICU stay correlates with disease severity and hospital mortality (33, 37–39). Here, NFKB1 is linked to acute respiratory distress syndrome.