O-GlcNAc transferase (OGT) directly induces O-GlcNAcylation at YAP1 Ser109 and Thr241, and potentiates the pro-proliferation activity of YAP1 in pancreatic cancer and liver cancer cells (Peng et al., 2017; Zhang et al., 2017). Here, YAP1 is linked to familial pancreatic carcinoma.