High glucose stimulation improves the level of O-GlcNAcylation at YAP1 Thr241; in addition, O-GlcNAcylation enhances the stability and activity of YAP1, which subsequently induces cell proliferation and transformative phenotypes in hepatocellular carcinoma cells (HCC, THLE-3, and HL-7702 cell lines) (Zhang et al., 2017). This evidence concerns the gene YAP1 and hepatocellular carcinoma.