As mentioned in Section “Role of Hippo–YAP1/TAZ Signaling and Its Differentiation Output in Heart Development,” YAP1/TEAD1-OSM feedback cycle exacerbates heart failure and the progression of diabetic cardiomyopathy in HFD-fed mice following TAC (Ikeda et al., 2019b). This evidence concerns the gene YAP1 and heart failure.