Clinical ischemic heart disease and idiopathic dilated cardiomyopathy (DCM) is characterized by enhanced YAP1/TAZ protein levels and increased transcriptional activity with the resultant upregulation of target genes, such as ankyrin repeat domain 1, CTGF, and CYR61; moreover, this phenomenon was observed in the murine heart with desmin-related cardiomyopathy (Hou et al., 2017). Here, YAP1 is linked to familial dilated cardiomyopathy.