In the transgenic heart, MST1 overexpression was shown to enhance the phosphorylation of YAP1 Ser127 and induce inactivation of YAP1; this induced cardiomyocyte (CM) apoptosis and myocardial fibrosis (Yamamoto et al., 2003; Zhao et al., 2019). The gene discussed is YAP1; the disease is Myocardial fibrosis.