Because previous studies have shown that cardiac dysfunction in diabetic rats occurs 8 weeks after STZ injection (Lacombe et al., 2007; Ti et al., 2011), we performed CMKLR1-siRNA treatment in vivo 8 weeks after STZ injection to explore whether inhibition of CMKLR1 exerted a therapeutic effect on DCM. The gene discussed is CMKLR1; the disease is familial dilated cardiomyopathy.