With CMKLR1 gene silencing, the myocardiocyte cross-section area, cardiac fibrosis area, and TUNEL-positive ratio were reduced in the DCM+CMKLR1-siRNA group compared with the NC group (Figures 3B–D,F–H; p < 0.05∼p < 0.01). The gene discussed is CMKLR1; the disease is familial dilated cardiomyopathy.