Several inflammatory and autoimmune diseases are correlated with the increased expression of A20, such as polyarthritis, inflammatory bowel disease, cystic fibrosis, and chronic inflammatory lung disease (Kang et al., 2009; Catrysse et al., 2014; Bannon et al., 2015; Momtazi et al., 2019). Here, TNFAIP3 is linked to cystic fibrosis.