Vinculin, paxillin, talin, zyxin, VASP, FAK, p130Cas, and alpha-actinin appear diffuse in human fibrosarcoma cells within 3D gels (Fraley et al., 2010), while py-paxillin appears diffuse in MDA-MB-231 cells within confined microchannels (Balzer et al., 2012). The gene discussed is PXN; the disease is fibrosarcoma.