Despite the controversial data regarding total and HMW adiponectin in physical activity, there is a mechanism by which adiponectin participates in exercise-induced anti-inflammatory functions and/or cardiovascular health, as suggest by the direct correlation of adiponectin with severity of diseases in cystic fibrosis that are strongly modulated by physical activity and also by the direct correlation of adiponectin with monocytes in water polo athletes by Nigro et al. (2016) and also reducing oxidative stress through activation of sirtuins pathways (Nigro et al., 2016; Polito et al., 2019). Here, ADIPOQ is linked to cystic fibrosis.