ADIPOQ and immune system disorder: Finally, human studies have demonstrated a strong modulation of Adiponectin serum concentrations and its receptors in course of immune disorders, powerfully suggesting that Adiponectin has an active role in regulating immune responses (Çoban et al., 2017; Dini et al., 2017; Pecoraro et al., 2017; Lee and Bae, 2018; Polito et al., 2019).