Interestingly, TRPM7 has been observed to be mutated in Guamanian ALS/PD patients (Hermosura et al., 2005) and TRPM7 expression is observed to be blunted in PD patients along with a similar decrease in neurotoxin models of PD (Sun et al., 2015). The gene discussed is TRPM7; the disease is amyotrophic lateral sclerosis.