G. lucidum polysaccharide can inhibit colon expansion of colorectal cancer (CRC) mice and reduce mortality by 30%, by alteration of reduced the relative abundance (RA) of cecal Oscillospira– which was first observed in CRC mice, and down-regulation of four cancer-related genes (Acaa1b, Fabp4, Mgll, and Scd1) expression of colonic epithelial cells (Luo et al., 2018). This evidence concerns the gene MGLL and colorectal carcinoma.