Evidence showed that PPARγ may also involve in lipid metabolism (Han et al., 2017), the obesity associated with chronic hypoxia can lead to severe endothelium-dependent diastolic dysfunction, resulting in obstructive sleep apnea (OSA), whereas the PPARγ agonist can significantly improve endothelial diastolic function and thus inhibit OSA (Zhang et al., 2017). The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.