Chen et al. showed that the FAK-mediated nuclear factor kappa B (NF-κB) signaling pathway was involved in Ang II-accelerated atherosclerosis, characterized by the atherosclerotic lesion macrophage content and plaque instability increased (Chen et al., 2018), indicating that FAK may active non-adhesion dependent signals to accelerate AS. This evidence concerns the gene PTK2 and atherosclerosis.