PPARG and obesity disorder: Evidence showed that PPARγ may also involve in lipid metabolism (Han et al., 2017), the obesity associated with chronic hypoxia can lead to severe endothelium-dependent diastolic dysfunction, resulting in obstructive sleep apnea (OSA), whereas the PPARγ agonist can significantly improve endothelial diastolic function and thus inhibit OSA (Zhang et al., 2017).