Importantly, hERG1 as well as Kv3.4 and IK seem to be critically required not only for CaMKIIs activation but also for cell cycle arrest in irradiated CML [(Palme et al., 2013) and present study), T cell leukemia (Klumpp et al., 2016), and glioblastoma cells (Stegen et al., 2015)], since pharmaceutical or molecular biological targeting of these channels overrides cell cycle arrest resulting in premature (i.e., with unfixed DNA double strand breaks) entry in mitosis and cell death. This evidence concerns the gene IK and glioblastoma.