To this end, K562 CML cells and—in further experiments—primary CML cells were used as in vitro models since K562 cells reportedly express hERG1 (Smith et al., 2002) and respond to ionizing radiation with elevated Kv3.4 (Palme et al., 2013) and other plasmalemmal ion channel activity and Ca2+ signaling (Heise et al., 2010). The gene discussed is KCNC4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.