For instance, in Jurkat T cell leukemia and K562 CML cells, TRPM2 (member 2 of the melastatin family of transient receptor potential) (Klumpp et al., 2016) and TRPV5/6-like (member 5/6 of the vanilloid family of TRP) Ca2+-permeable nonselective cation channels (Heise et al., 2010) have been proposed to generate radiogenic Ca2+ signals in concert with IK (Klumpp et al., 2016) and Kv3.4 (Palme et al., 2013) K+ channels, respectively. This evidence concerns the gene KCNC4 and chronic myelogenous leukemia, BCR-ABL1 positive.