Similarly to the proposed antagonistic action of Kv3.4 and hERG1 in K562 cells, IK channel inhibition either decreases steady state c[Ca2+]free or induces oscillation in c[Ca2+]free in glioblastoma cells while BK channel blockage results in an rapid increase in steady state c[Ca2+]free (Stegen et al., 2016). Here, KCNC4 is linked to glioblastoma.