Compared with NASH model group, the liver protein expression of Nrf2 and the Nrf2-controlled anti-oxidative genes HO-1, NQO1, r-GCS, and GST were significantly up-regulated by TFCH treatments and concentration-dependent increase in Nrf2 and the Nrf2-controlled antioxidant genes levels were also observed (all p <0.01vs model group). Here, NFE2L2 is linked to metabolic dysfunction-associated steatohepatitis.