TNF and cancer: KEGG enrichment analysis based on these 6 top targets showed that 39 signaling pathways were involved in the effects of inducing cancer cell apoptosis and autophagy (Figure 2C and Table S5), while p53, Neurotrophin, Sphingolipid, PI3K-Akt, Thyroid hormone, MAPK, VEGF, HIF-1, TNF signaling pathway and Adrenergic signaling in cardiomyocytes were the top 10 pathways (Figure 2D).