No change of Sirt1 protein expression in the parietal cortex of 12–20-month-old 3xTg-AD mice has been reported (Julien et al., 2009), and some studies do not reveal the difference in Sirt1 level in AD patients when compared with the healthy elderly (Furuya et al., 2012). This evidence concerns the gene SIRT1 and Alzheimer disease.